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Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Themes Researchers JP Top Medical Development of preventive medicine for aortic aneurysm and dissection of Marfan syndrome Development of preventive medicine for aortic aneurysm and dissection of Marfan syndrome JAPANESEINQUIRY update：2020/06/16       NEXT PREV Features and Uniqueness Marfan’s syndrome (MF) is a severe, systemic disorder of connective tissue formation. A variety of MFS therapies have been developed, including surgical therapy for aortic root aneurysm and dissection (AAD) that are life-threatening, traditional medical therapies such as β-adrenergic receptor or angiotensin II receptor blockers for slow aortic growth and to decrease the risk of AAD. However these treatments did not prevent tissue destruction in the AAD of MF. To develop preventive strategy for AAD, it will be necessary to identify molecular mechanisms of microfibril formation and an appropriate fibrillin-1 microfibril associated molecule. Recently, ADAMTSL6β, which is a microfibril-associated extracellular matrix protein contributes the regeneration of microfibril by promoting fibrillin-microfibril assembly. We try to develop ADAMTSL6β as a preventive medicine for AAD of MF by regeneration of fibrillin-1 microfibril assembly. Keywords Marfan syndrome Extracellular matrix Aortic aneurysm and disection Microfibril Connective tissue disease Researchers Graduate School of Dentistry Masahiro Saito, ProfessorDoctor of Dentistry researchmap researchmap Related Information M.Saito, T.Tsuji, Extracellular matrix administration as a potential therapeutic strategy for periodontal ligament regeneration. Expert Opin Biol Ther, Mar;12(3):299-309, 2012M. Saito, M. Kurokawa, M. Oda, M. Oshima, K. Tsutsui, K. Kosaka, K. Nakao, M. Ogawa, R. Manabe, N. Suda, G. Ganjargal, Y. Hada, T. Noguchi, T. Teranaka, K. Sekiguchi, T. Yoneda and T. Tsuji. ADAMTSL6Lβ rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly. J Biol Chem. 2011 4;286(44):38602-38613 Browsing History User Who Reviewed This Content Also Reviewed Extracorporeal Shock Wave Therapy as a New, Non-Invasive Angiogenic Therapy [ SHIMOKAWA Hiroaki Professor ] Molecular Imaging from Basic Research to Clinical Application [ YANAI Kazuhiko Professor ] Noninvasive Ultrasonic Measurement of Dynamic Properties of Heart and Arteries [ Hiroshi Kanai Professor ] Research Profiles ©TOHOKU UNIVERSITY How to Use FAQ For Researchers Site Policy [jp] ©TOHOKU UNIVERSITY Fields Medical Life Sciences Information Communication Environment Nanotechnology / Materials Energy Manufacturing Technology Social Infrastructure Frontier Liberal Arts Fields Themes Researchers 日本語 ENGLISH Close