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Diphenylmethanol derivatives are used as raw materials in the manufacture of perfumes and pharmaceuticals, among others.The researchers discovered that alumina can be repeatedly reused for this reaction if it is washed with water and dried between usages. This recycling reduces both the need for more alumina and the amount of waste produced, lowering synthesis costs and the impact on the environment. As global environmental awareness continues to increase, the researchers hope that this new method of chemical synthesis will contribute towards realizing a carbon neutral society and achieving the SDGs.This discovery was made by an international research group, which included Associate Professor TSUDA Akihiko of Kobe University Graduate School of Science (who is also a visiting professor at Inner Mongolia Medical University) and researchers from Inner Mongolia Medical University, including Professor CHAOLU Eerdun (who obtained their PhD. from Kobe University’s Graduate School of Science) and Lecturer LIANG Fengying.A patent application for this method was filed in China in April 2021, with a priority claim application made in September of the same year. Subsequently, the results of this research were published online in the academic journal ‘ChemistryOpen’ on May 18, 2022.Main pointsChina is the world’s biggest producer of alumina, producing 77.48 million tons in 2021 (source: JOGMEC Mineral Resources Information). Various useful functions of alumina have been discovered; it is recyclable and it can be used as a catalyst, an adsorbent and for organic synthesis.The researchers successfully produced high yields of diphenylmethanol derivatives via a simple process. This involved reacting two generic organic solvents together (chloroform and a methyl-substituted benzene) with inexpensive aluminium chloride serving as the catalyst. The product of this reaction was then treated with alumina containing water.This process does not require high-cost specialist equipment nor chemicals; the alumina can be repeatedly reused simply by washing it with water and then drying it, making it a simple, safe and low cost catalyst for organic synthesis.Scientific methods using new chemical reactions that are low energy/ have a low environmental impact will greatly contribute towards achieving carbon neutrality and the SDGs.This discovery was the result of an international joint research project in which overseas researchers who obtained their doctoral degrees from Kobe University received support for their research activities after leaving Japan.Research BackgroundFigure 1. A commercially available alumina powderAlumina (Al2O3) is an aluminium oxide mainly used as a raw material for the production of aluminium (Figure 1). However, it is also utilized as a catalyst in the field of organic synthetic chemistry. It is mainly used for reactions that require harsh conditions (such as high temperature or high pressure). However, alumina is not a commonly-used catalyst for various reasons, one being that it can only be used for a small range of chemical reactions. Alumina is also used to adsorb impurities in the organic synthesis field and as a stationary phase substance in chromatography (*2). However, issues such as its high cost as a raw material and the large amount of non-burnable waste it generates means that there is a trend towards replacing it with substitutes. Under these circumstances, Professor Tsuda led a research group at Inner Mongolia University (China) that succeeded in developing a new, sustainable method of organic synthesis using alumina, which China produces in great quantities.Professor Tsuda has been conducting international joint research with Inner Mongolia Medical University since 2017; he became a visiting professor in 2018, and has supervised the research of university members. He has been engaged in the joint development of pharmaceuticals, polymers and functional materials using the natural resources (such as metallic minerals and plants) found in the Inner Mongolia Autonomous Region. Since the conclusion of an academic partnership agreement between Kobe University Graduate School of Science and Inner Mongolia Medical University’s Department of Pharmaceutical Sciences in November 2021, the two institutions have been conducting more active inter-institutional research.Research MethodologyProfessor Tsuda and the Inner Mongolia Medical University team discovered a simple, low-cost, environmentally-friendly way of synthesizing diphenylmethanol derivatives (which are starting materials in the production of fragrances and pharmaceuticals) by utilizing Chinese alumina as both a catalyst and adsorbent (Figure 2). Using aluminium chloride (AlCl3) as a catalyst, the generic organic solvents toluene, xylene, and trimethylbenzene were reacted with chloroform. If the resulting substance is post-treated with water, then you mainly obtain a chlorination product. However, the researchers discovered that if the same resulting substance is deposited on alumina that contains water, you can obtain diphenylmethanol derivatives. They also found that if the resulting substance is deposited on alumina that contains methanol, a methanol substitute is obtained. It is thought that when the substance is adsorbed onto the alumina, it reacts with the water or alcohol within to produce the respective end product.Furthermore, the research group found that a highly pure product could be obtained even if it was adsorbed by alumina that had previously been used as a catalyst or was an impure by-product. Using the aforementioned method it is possible to selectively synthesize three different products.Figure 2. The new synthetic method for producing diphenylmethanol derivatives developed in this study: Product conversion using an alumina catalystFigure 3. Work-up of the product formed upon AlCl3-mediated Friedel-Crafts alkylation with alumina and initialization of the used alumina.However, commercial alumina is comparatively expensive, which would make it difficult to implement reactions like this that require large amounts on an industrial scale. With this in mind, the researchers tried reusing the alumina after rinsing it with water and allowing it to dry, and discovered that it retained its catalytic and adsorbent properties (Figure 3). This recycling process can be performed repeatedly, which greatly reduces the cost of materials as well as the amount of waste. For the synthesis experiments in the laboratory, the amount of alumina used was in the region of a few grams to tens of grams. It is a safe, high-yield reaction that only takes a short amount of time to complete (a number of hours), therefore this application of alumina on an academic level could be expanded into diverse fields in the chemical industry. It is hoped that it could provide society with a practical and sustainable organic synthesis method.Detailed process and mechanism:At 0°C, aluminium chloride (1.1 g, 8 mmol) was added to a mixture of chloroform (30 mL, 0.37 mol) and an aromatic substrate such as p-xylene (1mL, 8mmol), and then stirred for 6 hours. After this, the resulting sample solution was dropped into a commercially available alumina column (water content ~1 wt%) and subjected to column chromatography with a dry chloroform/ethyl acetate (1:1) eluent. This chromatography revealed that a 94% yield of diphenylmethanol derivatives can be produced using this method. Refinement processes such as recrystallization can be performed as required to obtain a highly pure end product.As for the mechanism behind this, it is thought that the chloroform and the aromatic substrate undergo an aluminium chloride-mediated Friedel-Crafts reaction. The resulting reactant and aluminium chloride are adsorbed by the alumina and are subsequently hydrolysed by the water molecules in the alumina, leading to the formation of the end product.  After removing the end product from the alumina, the alumina can be recycled by first washing away the adsorbed compounds, salts and solvents remaining in the alumina and then drying it. Consequently, the alumina can be reused as a catalyst for this reaction again and again.Further ResearchThe novel catalytic, adsorbent and recyclable properties of alumina discovered through this research have potential applications to the organic synthesis of compounds other than diphenylmethanol derivatives. The goal is to greatly expand this reaction’s range of applications to develop a more general synthesis method that can be used to produce various useful chemicals.Amidst rising global environmental awareness, it is hoped that the new chemical reaction developed in this study will become a novel method of synthesizing chemical products which will contribute towards recycling efforts, carbon neutrality and the SDGs. It is predicted to bring about fresh innovation in the organic synthesis and organic chemical industries. It is hoped that continued development of this method through the international research collaboration with China, the world’s number one producer of alumina, will result in highly practical large-scale implementation.About the Research System and FundingThis was an international joint research study conducted by the Department of Pharmaceutical Sciences at Inner Mongolia Medical University and the Graduate School of Science at Kobe University. The research was funded by a grant from The National Natural Science Fund of China (NSFC) (grant number: 21961026).Glossary1. Inner Mongolia Medical UniversityA medical university located in the Inner Mongolia Autonomous Region. It was the first medical university to be founded in one of China’s ethnic minority regions. It is one of the designated institutions in the PRC Ministry of Education’s plan to educate outstanding medical students.2. ChromatographyAn analytical technique for separating a mixture into its components. A gas, liquid, or supercritical fluid is used as a mobile phase which carries the mixture though a system (in this case a column apparatus or tube) where it interacts with a substances used as a stationary phase. Different components of the mixture travel through specific mobile and stationary phases at different speeds, causing them to separate and allowing the components of the mixture to be detected.Patent DetailsPresentation Title: Synthesis method for diphenylmethanol derivatives (Chinese title: 二苯甲醇衍生物的制备方法)Domestic Application No. (China): 202110401595.1 (Date of Application: April 14, 2021)Priority Claim Application No. (China): 202111035281.0 (Date of Application: September 5, 2021)Presenters: Chaolu Eerdun and Akihiko TsudaApplicant: Inner Mongolia Medical UniversityJournal InformationTitle“Direct Syntheses of Diphenylmethanol Derivatives from Substituted Benzenes and CHCl3 through Friedel-Crafts Alkylation and Post Hydrolysis or Alcoholysis Catalyzed by Alumina”DOI10.1002/open.202200042Authors苏日古嘎 (Guga Suri) +,[a] 梁凤英(Fengying Liang) +,[a] 胡密霞 (Mixia Hu),[a] 王美玲 (Meiling Wang),[a] 布仁 (Ren Bu),[a] 张笑迎 (Xiaoying Zhang),[a] 王慧 (Hui Wang),[a] 董文艳 (Wenyan Dong),[a] 额尔敦 (Chaolu Eerdun),*[a] 津田明彦 (Akihiko Tsuda)*[a,b]* Corresponding author, + Equal contribution[a] Department of Pharmaceutical Sciences, Inner Mongolia Medical University[b] Graduate School of Science, Kobe UniversityJournalChemistryOpenResearchersTsuda AkihikoAssociate ProfessorGraduate School of ScienceSDGs)">)">)">)">Graduate School of ScienceSHAREMore from these researchersPress releases2024.01.11ChemistryDry-cleaning fluid becomes a synthetic chemist's treasurePress releases2023.09.19ChemistryKeeping Vilsmeier reagent in the flowPress releases2023.08.08ChemistrySuccessful polycarbonate synthesis using the photo-on-demand interfacial polymerization methodPress releases2023.07.21ChemistryNew method for polyurethane synthesis using fluorine compound developed jointly by Kobe University and AGC Inc.More about these topicsPress releases2022.11.22ChemistryKey to Chemical Industries’ Sustainable Future?Press releases2022.10.28ChemistrySafe, sustainable photo-on-demand synthesis of polypeptide precursorsPress releases2022.09.22ChemistryDeveloping fluoroalkyl carbonates to make pharmaceutical and chemical industries cleaner and saferPress releases2023.02.01ChemistryKobe University and AGC successfully convert dry cleaning solvent into useful chemical compoundsページの先頭へ1-1, Rokkodai-cho, Nada-ku, Kobe, 657-8501, JAPANProspective studentsCurrent studentsAlumsCorporate and societyFaculty and staffContactAccessJobsOfficial social media accountsCampus calendarPrivacy policySite policySite map© Kobe University