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研究者情報 研究者基礎情報 研究者情報 学歴 経歴 所属学協会 研究者活動情報 研究分野 研究キーワード 委員歴 受賞 担当経験のある科目(授業) 論文 MISC 書籍等出版物 講演・口頭発表等 Works(作品等) 共同研究・競争的資金等の研究課題 産業財産権 社会貢献活動 メディア報道 学術貢献活動 その他(研究者活動情報) その他教育活動 修士・博士論文指導等 基本情報 氏名 信久　幾夫 氏名（カナ） ﾉﾌﾞﾋｻ ｲｸｵ 氏名（英語） NOBUHISA IKUO 所属 中村学園大学 栄養科学部 栄養科学科 職名 教授 研究者基礎情報 研究者情報 信久　幾夫　ノブヒサ　イクオ 学歴 1995-04　1998-03　九州大学　理学研究科　化学専攻 1993-04　1995-03　九州大学　理学研究科　化学専攻 1989-04　1993-03　九州大学　理学部　化学科 経歴 1995-04　1998-03　日本学術振興会　九州大学大学院理学研究科 化学専攻　その他　特別研究員(DC1) 1998-04　2000-07　日本学術振興会　九州大学大学院医学系研究科　その他　特別研究員(PD) 1998-04　2000-07　日本学術振興会　九州大学大学院医学系研究科　その他　特別研究員(PD) 2000-08　2005-03　熊本大学　発生医学研究センター 転写制御学分野　助手 2005-04　2009-03　熊本大学　発生医学研究センター 転写制御学分野　講師 全て表示する（12件） 2009/04　2021/03　東京医科歯科大学　難治疾患研究所 先端分子医学研究部門 幹細胞制御　准教授 2009/04　2021/03　東京医科歯科大学　大学院医歯学総合研究科 医歯学系専攻 器官システム制御学講座 幹細胞制御　准教授 2009/04　2021/03　東京医科歯科大学　大学院医歯学総合研究科 医歯学系専攻 器官システム制御学講座 幹細胞制御　准教授 2021-04　東京医科歯科大学　難治疾患研究所 2021-04　中村学園大学　栄養科学部栄養科学科　教授 2021-09　2022-03　新潟大学　理学部 2022-04　福岡大学　理学部 表示を折りたたむ 所属学協会   研究者活動情報 研究分野 ライフサイエンス　栄養学、健康科学 ライフサイエンス　発生生物学 ライフサイエンス　細胞生物学 ライフサイエンス　分子生物学 研究キーワード 造血 委員歴 2021-06　日本生化学会 九州支部評議委員 受賞   担当経験のある科目(授業) 生物有機化学　中村学園大学 人体の生化学　中村学園大学 実験・人体の生化学　中村学園大学 栄養生化学特論　中村学園大学 ミクロの生物科学　分子生物学入門　福岡大学 全て表示する（16件） 生命の分子的基盤実習　東京医科歯科大学 幹細胞制御学特論、通年　東京医科歯科大学 幹細胞制御学演習、通年　東京医科歯科大学 幹細胞制御学演習　東京医科歯科大学 幹細胞制御学実験、通年　東京医科歯科大学 化学特論III 「幹細胞」　新潟大学 全学教育（フレッシュマンセミナー）体の社会学—幹細胞研究の基礎 「造血幹細胞」　北海道大学 修士課程「生化学」　東京医科歯科大学 コース特論「発生・再構築学コース」コース授業　東京医科歯科大学 コース特論「発生・再構築学コース」　東京医科歯科大学 Advanced Study of Nutritional Biochemistry　Nakamura Gakuen University 表示を折りたたむ 論文 Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment　共著　Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama KI, Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T,… Miyakawa T.　2024/03 A Sox17 downstream gene Rasip1 is involved in the hematopoietic activity of intra-aortic hematopoietic clusters in the midgestation mouse embryo.　共著　Melig G, Nobuhisa I, Saito K, Tsukahara R, Itabashi A, Kanai Y, Kanai-Azuma M, Osawa M, Oshima M, Iwama A, Taga T　2023/08 Glioma cells remotely promote erythropoiesis as a self-expanding strategy of cancer stem cells　Aimaitijiang ATabu KWang WNobuhisa ITaga T　Genes Cells　2022-01 Sry-related High Mobility Group Box 17 functions as a tumor suppressor by antagonizing the Wnt pathway　Anani MNobuhisa ITaga T　Journal of Cancer Prevention　2020-12 Sox17-mediated expression of adherent molecules is required for the maintenance of undifferentiated hematopoietic cluster formation in midgestation mouse embryos　Takahashi SNobuhisa ISaito KMelig GItabashi AHarada KOsawa MEndo ATIwama ATaga T　Differentiation　2020-09 全て表示する（65件） Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis/Kiyoka SaitoIkuo NobuhisaKaho HaradaSatomi TakahashiMaha AnaniHeiko LickertMasami Kanai-AzumaYoshiakira KanaiTetsuya Taga/Experimental Cell Research Thrombopoietin contributes to the formation and the maintenance of hematopoietic progenitor-containing cell clusters in the aorta-gonad-mesonephros region/Kaho HaradaIkuo NobuhisaMaha AnaniKiyoka SaitoTetsuya Taga/CYTOKINE A Synthetic Polymer Scaffold Reveals the Self-Maintenance Strategies of Rat Glioma Stem Cells by Organization of the Advantageous Niche/Kouichi TabuNozomi MuramatsuChristian ManganiMei WuRong ZhangTaichi KimuraKazuo TerashimaNorihisa BizenRyosuke KimuraWenqian WangYoshitaka MurotaYasuhiro KokubuIkuo NobuhisaTetsushi KagawaIssay KitabayashiMark BradleyTetsuya Taga/STEM CELLS Induction of protumoral CD11c(high) macrophages by glioma cancer stem cells through GM-CSF/Yasuhiro KokubuKouichi TabuNozomi MuramatsuWenqian WangYoshitaka MurotaIkuo NobuhisaMasahisa JinushiTetsuya Taga/GENES TO CELLS Sox17 as a candidate regulator of myeloid restricted differentiation potential/Maha AnaniIkuo NobuhisaMitsujiro OsawaAtsushi IwamaKaho HaradaKiyoka SaitoTetsuya Taga/DEVELOPMENT GROWTH & DIFFERENTIATION Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters/Ikuo NobuhisaMitsujiro OsawaMami UemuraYoko KishikawaMaha AnaniKaho HaradaHaruna TakagiKiyoka SaitoMasami Kanai-AzumaYoshiakira KanaiAtsushi IwamaTetsuya Tagaa/Molecular and Cellular Biology Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL/6 background mice/Mami UemuraAisa OzawaTakumi NagataKaoruko KurasawaNaoki TsunekawaIkuo NobuhisaTetsuya TagaKenshiro HaraAkihiko KudoHayato KawakamiYukio SaijohMasamichi KurohmaruMasami Kanai-AzumaYoshiakira Kanai/Development (Cambridge) CD45(low)c-Kit(high) cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region/Ikuo NobuhisaShoutarou YamasakiAhmed RamadanTetsuya Taga/EXPERIMENTAL CELL RESEARCH Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression/Shoutarou YamasakiIkuo NobuhisaAhmed RamadanTetsuya Taga/DEVELOPMENT GROWTH & DIFFERENTIATION Cells with hematopoietic activity in the mouse placenta reside in side population/Ahmed RamadanIkuo NobuhisaShoutarou YamasakiNaomi NakagataTetsuya Taga/GENES TO CELLS Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.　Inoue TKagawa TInoue-Mochita MIsono KOhtsu NNobuhisa IFukushima MTanihara HTaga T　FEBS Letters　2010-06 Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.　Inoue TKagawa TInoue-Mochita MIsono KOhtsu NNobuhisa IFukushima MTanihara HTaga T　FEBS Letters　2010-06 Identification of the B Subtype of gamma Phospholipase A(2 9 Inhibitor from Protobothrops flavoviridis Serum and Molecular Evolution of Snake Serum Phospholipase A(2) Inhibitors.　So SChijiwa TIkeda NNobuhisa IOda-Ueda NHattori SOhno M　J Mol Evol　2008-03 Identification of the B Subtype of gamma Phospholipase A(2 9 Inhibitor from Protobothrops flavoviridis Serum and Molecular Evolution of Snake Serum Phospholipase A(2) Inhibitors.　J Mol Evol　2008-03 Identification of a population of cells with hematopoietic stem cell properties in mouse aorta-gonad-mesonephros cultures/Ikuo NobuhisaNaoki OhtsuSeiji OkadaNaomi NakagataTetsuya Taga/EXPERIMENTAL CELL RESEARCH Inhibitory effects of homeodomain-interacting protein kinase 2 on the aorta-gonad-mesonephros hematopoiesis/Naoki OhtsuIkuo NobuhisaMiyuki MochitaTetsuya Taga/EXPERIMENTAL CELL RESEARCH Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47(phox) in recognition of a polyproline type II helix and an adjacent alpha-helix of p22(phox)/Nobuhisa, IR TakeyaK OguraN UenoD KohdaF InagakiH Sumimoto/BIOCHEMICAL JOURNAL Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk/H TakizawaC Kubo-AkashiNobuhisa, ISM KwonM IsekiT TagaK TakatsuS Takaki/BLOOD Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk/H TakizawaC Kubo-AkashiNobuhisa, ISM KwonM IsekiT TagaK TakatsuS Takaki/BLOOD NMR solution structure of the tandem SH3 domains of p47phox complexed with a p22phox –derived proline-rich peptide.　Ogura KNobuhisa IYuzawa STakeya RTorikai SSaikawa KSumimoto HInagaki F　J Bioi Chem　2006-02 NMR solution structure of the tandem SH3 domains of p47phox complexed with a p22phox –derived proline-rich peptide.　Ogura KNobuhisa IYuzawa STakeya RTorikai SSaikawa KSumimoto HInagaki F　J Bioi Chem　2006-02 A region C-terminal to the proline-rich core of p47(phox) regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67(phox)/K MizukiR TakeyaF KuribayashiNobuhisa, ID KohdaH NunoiK TakeshigeH Sumimoto/ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS A region C-terminal to the proline-rich core of p47(phox) regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67(phox)/K MizukiR TakeyaF KuribayashiNobuhisa, ID KohdaH NunoiK TakeshigeH Sumimoto/ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture/M YanagisawaK NakashimaW OchiaiT TakizawaT SetoguchiA UemuraM TakizawaNobuhisa, IT Taga/NEUROSCIENCE RESEARCH Fate redirection of hippocampal astrocytes toward neuronal lineage by aggregate culture/M YanagisawaK NakashimaW OchiaiT TakizawaT SetoguchiA UemuraM TakizawaNobuhisa, IT Taga/NEUROSCIENCE RESEARCH Targeted disruption of the mouse ELYS gene results in embryonic lethality at peri-implantation development.　Genes Cells　2004-11 Targeted disruption of the mouse ELYS gene results in embryonic lethality at peri-implantation development.　Okita KKiyonari HNobuhisa IKimura NAizawa STaga T　Genes Cells　2004-11 Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan.　Chijiwa TDeshimaru MNobuhisa INakai MOgawa TOda NNakashima KFukumaki YShimohigashi YHattori SOhno M　Biochem J　2004-04 Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan.　Chijiwa TDeshimaru MNobuhisa INakai MOgawa TOda NNakashima KFukumaki YShimohigashi YHattori SOhno M　Biochem J　2004-04 Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation/Nobuhisa, IR KatoH InoueM TakizawaK OkitaA YoshimuraT Taga/JOURNAL OF EXPERIMENTAL MEDICINE Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product.　Biochem Biophys Res Commun　2004-01 Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein.　Mol Cell Biol　2003-12 Genomic organization and characterization of the mouse ELYS gene.　Biochem Biophys Res Commun　2003-05 Requirement of gp130 signaling for the AGM hematopoiesis.　Exp Hematol　2003-04 Interisland evolution of Trimeresurus flavoviridis venom phospholipase A(2) isozymes/T ChijiwaY YamaguchiT OgawaM DeshimaruNobuhisa, IK NakashimaN Oda-UedaY FukumakiS HattoriM Ohno/JOURNAL OF MOLECULAR EVOLUTION Interisland Evolution of Trimeresurus flavoviridis Venom Phospholipase A2 Isozymes.　J Mol Evol　2003-03 Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues.　Genes Cells　2002-04 Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion.　Biochem Biophys Res Commun　2001-09 Regional and accelerated molecular evolution in group I snake venom gland phospholipase A(2) isozymes/Y ChumanNobuhisa, IT OgawaM DeshimaruT ChijiwaNH TanY FukumakiY ShimohigashiF DucancelJC BoulainA MenezM Ohno/TOXICON Regional and accelerated molecular evolution in group I snake venom gland phospholipase A(2) isozymes/Y ChumanNobuhisa, IT OgawaM DeshimaruT ChijiwaNH TanY FukumakiY ShimohigashiF DucancelJC BoulainA MenezM Ohno/TOXICON Structural elements of Trimeresurus flavoviridis serum inhibitors for recognition of its venom phospholipase A(2) isozymes/Nobuhisa, IT ChiwataY FukumakiS HattoriY ShimohigashiM Ohno/FEBS LETTERS Retrotransposable CR1-like elements in crotalinae snake genomes/Nobuhisa, IT OgawaM DeshimaruT ChijiwaK NakashimaY ChumanY ShimohigashiY FukumakiS HattoriM Ohno/TOXICON Structural elements of Trimeresurus flavoviridis serum inhibitors for recognition of its venom phospholipase A(2) isozymes/Nobuhisa, IT ChiwataY FukumakiS HattoriY ShimohigashiM Ohno/FEBS LETTERS Retrotransposable CR1-like elements in crotalinae snake genomes/Nobuhisa, IT OgawaM DeshimaruT ChijiwaK NakashimaY ChumanY ShimohigashiY FukumakiS HattoriM Ohno/TOXICON Characterization and evolution of a gene encoding a Trimeresurus flavoviridis serum protein that inhibits basic phospholipase A(2) isozymes in the snake's venom/Nobuhisa, IS InamasuM NakaiA TatsuiT MimoriT OgawaY ShimohigashiY FukumakiS HattoriH KiharaM Ohno/EUROPEAN JOURNAL OF BIOCHEMISTRY Characterization and evolution of a gene encoding a Trimeresurus flavoviridis serum protein that inhibits basic phospholipase A(2) isozymes in the snake's venom/Nobuhisa, IS InamasuM NakaiA TatsuiT MimoriT OgawaY ShimohigashiY FukumakiS HattoriH KiharaM Ohno/EUROPEAN JOURNAL OF BIOCHEMISTRY Structures of genes encoding phospholipase A(2) inhibitors from the serum of Trimeresurus flavoviridis snake/Nobuhisa, IM DeshimaruT ChijiwaK NakashimaT OgawaY ShimohigashiY FukumakiS HattoriH KiharaM Ohno/GENE Structures of genes encoding phospholipase A(2) inhibitors from the serum of Trimeresurus flavoviridis snake/Nobuhisa, IM DeshimaruT ChijiwaK NakashimaT OgawaY ShimohigashiY FukumakiS HattoriH KiharaM Ohno/GENE Accelerated evolution of snake venom phospholipase A(2) isozymes for acquisition of diverse physiological functions/T OgawaK NakashimaNobuhisa, IM DeshimaruY ShimohigashiY FukumakiY SakakiS HattoriM Ohno/TOXICON Accelerated Evolution of Crotalinae Snake Venom Gland Serine Proteases.　Deshimaru MOgawa TNakashima KNobuhisa IChijiwa TShimohigashi YFukumaki YNiwa MYamashina IHattori SOhno M　FEBS Letters　1996-11 Accelerated evolution of snake venom phospholipase A(2) isozymes for acquisition of diverse physiological functions/T OgawaK NakashimaNobuhisa, IM DeshimaruY ShimohigashiY FukumakiY SakakiS HattoriM Ohno/TOXICON Accelerated Evolution of Crotalinae Snake Venom Gland Serine Proteases.　FEBS Letters　1996-11 Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A(2) isozyme-encoding genes/Nobuhisa, IK NakashimaM DeshimaruT OgawaY ShimohigashiY FukumakiY SakakiS HattoriH KiharaM Ohno/GENE Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A(2) isozyme-encoding genes/Nobuhisa, IK NakashimaM DeshimaruT OgawaY ShimohigashiY FukumakiY SakakiS HattoriH KiharaM Ohno/GENE ACCELERATED EVOLUTION IN THE PROTEIN-CODING REGIONS IS UNIVERSAL IN CROTALINAE SNAKE-VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMANOBUHISA, IM DESHIMARUM NAKAIT OGAWAY SHIMOHIGASHIY FUKUMAKIM HATTORIY SAKAKIS HATTORIM OHNO/PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ACCELERATED EVOLUTION IN THE PROTEIN-CODING REGIONS IS UNIVERSAL IN CROTALINAE SNAKE-VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMANOBUHISA, IM DESHIMARUM NAKAIT OGAWAY SHIMOHIGASHIY FUKUMAKIM HATTORIY SAKAKIS HATTORIM OHNO/PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA STRUCTURES OF GENES ENCODING TATA BOX-BINDING PROTEINS FROM TRIMERESURUS-GRAMINEUS AND T-FLAVOVIRIDIS SNAKES/K NAKASHIMANOBUHISA, IM DESHIMARUT OGAWAY SHIMOHIGASHIY FUKUMAKIM HATTORIY SAKAKIS HATTORIM OHNO/GENE STRUCTURES OF GENES ENCODING TATA BOX-BINDING PROTEINS FROM TRIMERESURUS-GRAMINEUS AND T-FLAVOVIRIDIS SNAKES/K NAKASHIMANOBUHISA, IM DESHIMARUT OGAWAY SHIMOHIGASHIY FUKUMAKIM HATTORIY SAKAKIS HATTORIM OHNO/GENE POLYMORPHISMS OF TRIMERESURUS-FLAVOVIRIDIS VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMANOBUHISA, IT OGAWAM HATTORIY SAKAKIH KIHARAM OHNO/BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY POLYMORPHISMS OF TRIMERESURUS-FLAVOVIRIDIS VENOM GLAND PHOSPHOLIPASE A(2) ISOZYME GENES/KI NAKASHIMANOBUHISA, IT OGAWAM HATTORIY SAKAKIH KIHARAM OHNO/BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 表示を折りたたむ MISC   書籍等出版物 幹細胞（体性幹細胞・胚性幹細胞・iPS細胞）　沖田圭介信久幾夫田賀哲也　単著　バイオマテリアル：その基礎と先端研究への展開. 岡野光夫監修、田畑泰彦・塙隆夫編著 東京化学同人　2016-02 講演・口頭発表等 Rasip1 is a novel Sox17 downstream target gene and cooperating factor for the maintenance of the hematopoietic cluster cells　Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T.　第46回分子生物学会年会　2023/12/08 胎生期に造血幹細胞が出現し維持される仕組み　信久幾夫、田賀哲也　第96回 日本生化学会大会　2023/11/02　日本生化学会 Rasip1 helps maintenance of hematopoietic activities of mouse embryonic intra-aortic hematopoietic clusters.　Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T.　第44回日本炎症・再生医学会　2023/07/12 Rasip1 gene functioning downstream of Sox17 maintains the hematopoietic cluster-forming cells in E10.5 mouse embryos.　Melig G, Nobuhisa I, Kiyoka S, Tsukahara R, Itabashi A, Kanai Y, Kanai M, Taga T.　第20回幹細胞シンポジウム　2023/05/19 Rasip1 is involved in the positive regulation of hematopoietic activity in E10.5 intra-aortic hematopoietic cluster cells　Melig GNobuhisa IKiyoka STsukahara RItabashi AKanai YKanai MTaga T　第45回分子生物学会年会　2022-12-01 全て表示する（136件） Rasip1-mediated maintenance of Sox17-transduced intra-aortic hematopoietic cluster cells.　Melig GNobuhisa IKiyoka STsukahara RItabashi AKanai YKanai MTaga T　第43回日本炎症・再生医学会　2022-07-06 Investigating the function of Rasip1 in HSC-containing IAHCs of midgestation mouse embryos.　Melig GNobuhisa IKiyoka STsukahara RItabashi AKanai YKanai MTaga T　第19回幹細胞シンポジウム　2022-05-27　淡路夢舞台、淡路市 Rasip1 preserves the maintenance of the hematopoietic activity of cluster forming cells in E10.5 mouse embryos　Melig GNobuhisa IKiyoka STsukahara RItabashi AKanai YKanai MTaga T　第44回分子生物学会年会　2021-12-01 Sox17を導入した造血幹・前駆細胞の細胞塊形成能は発生の進行に伴い低下する　板橋歩未信久幾夫吉田大峰横居優貴齋藤清香塚原涼太Melig Gerel田賀哲也　第8回 JCRベーシックリサーチカンファレンス　2021-11-12 造血幹・前駆細胞のSox17導入による細胞塊形成能は発生の進行により低下する　板橋歩未信久幾夫吉田大峰横居優貴齋藤清香塚原涼太Melig Gerel田賀哲也　第42回日本炎症・再生医学会　2021-07-07 Involvement of Rasip1 in the maintenance of hematopoietic ability of intra-aortic hematopoietic cell clusters in midgestation mouse embryos　Melig GNobuhisa IKiyoka STsukahara RItabashi AKanai YKanai MTaga T　第42回日本炎症・再生医学会　2021-07-07 板橋歩未、信久幾夫、横居優貴、齋藤清香、塚原涼太、Melig Gerel、田賀哲也　転写因子S導入した造血幹前駆細胞の細胞塊形成能は発生の進行に伴い低下する　第43回分子生物学会年会　2020-12-02 Contribution of Rasip1 to the maintenance of hematopoietic activity of cluster-forming cells in midgestation mouse embryos　Melig GNobuhisa IKiyoka STsukahara RItabashi AKanai YKanai MTaga T　第43回分子生物学会年会　2020-12-02 Glioma stem cells promote erythroid differentiation in mouse bone marrow　Alapati AimaitijiangKouichi TabuWenqian WangIkuo NobuhisaTetsuya Taga　第41回日本炎症・再生医学会シンポジウム「炎症と発癌・転移の最前線」　2020-07-08 マウス胎仔肝臓・成体骨髄の造血幹細胞を含む細胞集団への転写因子Sox17強制発現による細胞塊形成と未分化性維持　板橋歩未信久幾夫横居優貴齋藤清香塚原涼太Melig Gerel田賀哲也　The 41th Annual Meeting of the Japanese Society of Inflammation and Regeneration　2020-07-08 Role of the Rasip1 in the hematopoiesis of HSC-containing hematopoietic cluster cells in midgestation of mouse embryos　Gerel MeligIkuo NobuhisaSaito KiyokaRyota TsukaharaAyumi ItabashiYoshiakira KanaiMasami KanaiTetsuya Taga　The 41th Annual Meeting of the Japanese Society of Inflammation and Regeneration　2020-07-08 胎生中期マウス内動脈内腔における転写因子Sox17を介したGIMAP6発現の造血能に対する寄与　信久幾夫塚原涼太齋藤清香金井克晃金井正美田賀哲也　第41回日本炎症・再生医学会　2020-07-08 Involvement of TET1 in the maintenance of the hematopoietic capacity in hematopoietic cell clusters in the dorsal aorta in midgestation mouse embryo　Nobuhisa ISaito KTsukahara RAzuma KMelig GItabashi ATaga T　The 48th Annual Meeting of The Japanese Society for Immunology　2019-12-11 The role of GIMAP family in the maintenance of hematopoietic capacity in hematopoietic cell cluster in midgestation mouse dorsal aorta　Tsukahara YNobuhisa ISaito KKanai YKanai MTaga T　The 42th Annual Meeting of the Molecular Biology Society of Japan　2019-12-02 Enhanced erythropoiesis in bone marrow of C6 glioma-bearing mice　Aimaitijiang ATabu KWang WNobuhisa ITaga T　The 17th Stem Cell Research Sympodium　2019-05-24 Systematic analysis of brain pH and lactate levels in animal models: relationships and implications for behavioral outcomes　Hagihara HShoji HKohno THayata ATamada KHori KTatsukawa TShibutani MWakatsuki SHagino YKasahara TNumakawa TOhtabi HNobuhisa IHoshiba YNakamura HKatori SYamanishi KTakamiya YTanaka MYalcin IMatsushita MHattori MHashimoto HTakumi THoshino MTabuchi KYamakawa KHatada IIkeda KKato TKunugi HToyoda ATaga THayashi-Takagi AGoshima YIwasato TOkabe SMeltzer HYMiyakawa T　The 21st Annual Meeting of the International Behavioural and Neural Genetics Society　2019-05-10　The International Behavioural and Neural Genetics Society The contribution of TET1 to the maintenance of the hematopoietic capacity in hematopoietic stem cell-containing clusters in the dorsal aorta in midgestation mouse embryo　Nobuhisa ISaito KAzuma KIizauka NTaga T　The 47th Annual Meeting of The Japanese Society for Immunology　2018-12-10 マウス胎生中期AGM領域におけるTetファミリー遺伝子の発現解析　齋藤 清香信久 幾夫田賀 哲也　第41回日本分子生物学会年会　2018-11-29 マウス胎生中期の大動脈内腔に存在する造血幹細胞含有細胞塊の未分化状態維持における NF-κ Bシグナルの寄与　飯塚 直樹信久 幾夫齋藤 清香東 康哉田賀 哲也　第41回日本分子生物学会年会　2018-11-29 成体型造血が出現する胎生期 AGM領域の未分化血液細胞塊におけるエピジェネティック因子 TET１の役割　東 康哉信久 幾夫斎藤 清香飯塚 直樹田賀 哲也　第41回日本分子生物学会年会　2018-11-29 Expression of TET family members in hematopoietic stem cell-containing clusters of the dorsal aorta in midgestation mouse embryo　Nobuhisa ISaito KTaga T　The 16th Stem Cell Research Symposium　2018-06-02 Role of adhesion molecules induced by a transcription factor Sox17 in intra-aortic hematopoietic cell cluster formation in midgestation mouse embryos　Nobuhisa ITakahashi SSaito KTaga T　The 46th Annual Meeting of The Japanese Society for Immunology　2017-12-12 The mechanism of maintaining the undifferentiated state of hematopoietic stem cell by Sox17 and TET family members　Saito KNobuhisa ITaga T　The 40th Annual Meeting of the Molecular Biology Society of Japan　2017-12-07 Involvement of transcription factor Sox17-mediated expression of adhesion molecules in hematopoietic cell cluster formation in midgestation mouse dorsal aorta　Takahashi SNobuhisa ISaito KTaga T　The 39th Annual Meeting of the Molecular Biology Society of Japan　2016-12-01 Maintenance of hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis　Saito KNobuhisa IAnani MHarada KTakahashi SLickert HKanai MKanai YTaga T　The 39th Annual Meeting of the Molecular Biology Society of Japan　2016-12-01 Mechanism of maintaining hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis　Saito KNobuhisa IAnani MHarada KTakahashi STaga T　The 14th Stem Cell Symposium　2016-05-20 Maintenance of hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region as a site of definitive hematopoiesis through the Sox17-Notch1-Hes1 axis　Saito KNobuhisa IAnani MHarada KTakahashi STaga T　The 38th Annual Meeting of the Molecular Biology Society of Japan　2015-12-01 Sox17 maintains the stem cell population of intra-aortic hematopoietic cell clusters in the aorta-gonad-mesonephros region through Notch signaling　Nobuhisa ISaito KTakahashi SHarada KAnani MTaga T　The 44th Annual Meeting of The Japanese Society for Immunology　2015-11-19 Maintenance of hematopoietic stem and progenitor cell phenotype of intra-aortic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis　Saito KNobuhisa IAnani MHarada KTakahashi STaga T　International Society for Experimental Hematology 44th Annual Scientific Meeting　2015-09-18 Sox17 is critical for the maintenance of stem cell phenotype of intra-aortic hematopoietic clusters of cells in the aorta-gonad-mesonephros region　Nobuhisa IOsawa MUemura MHarada KAnani MSaito KTakagi HTakahashi SKanai-Azuma MKanai YIwama ATaga T　International Society for Experimental Hematology 44th Annual Scientific Meeting　2015-09-17 Sox17 maintains the stem cell population of intra-aortic hematopoietic cell clusters in the aorta-gonad-mesonephros region　Nobuhisa ITaga T　The 10th International Symposium of the Institute Network　2015-07-23 Maintenance of intra-aortic hematopoietic cell clusters in the AGM region through the Sox17-Notch1-Hes1 axis　Saito KNobuhisa IAnani MHarada KTakahashi STaga T　The 13th Stem Cell Symposium　2015-05-29 Sustained expression of Sox17 in AGM-derived hematopoietic stem/progenitor cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors　Anani MNobuhisa IOsawa MIwama AHarada KSaito KTaga T　The 43rd Annual Meeting of The Japanese Society for Immunology　2014-12-11 Sustained expression of Sox17 in the aorta-gonad-mesonephros-derived hematopoietic cells maintain the self-renewal capacity and the hematopoietic ability to produce myeloid progenitors　Nobuhisa IAnani MOsawa MIwama AHarada KSaito KTaga T　The 37th Annual Meeting of the Molecular Biology Society of Japan　2014-11-26 Role of the Notch signaling pathway and its downstream genes in hematopoietic progenitor cell-containing cell clusters in the aorta-gonad-mesonephros region　Saito KNobuhisa IAnani MHarada KTaga T　The 37th Annual Meeting of the Molecular Biology Society of Japan　2014-11-25 Role of the Notch signaling pathway and its downstream genes in hematopoietic progenitor cell-containing cell clusters in the aorta-gonad-mesonephros region　Saito KNobuhisa IAnani MHarada KTaga T　The 37th Annual Meeting of the Molecular Biology Society of Japan　2014-11-25 Sox17-transduction imparts fetal hematopoietic cells with the myeloid-restricted differentiation potential　Anani MNobuhisa IOsawa MIwama AHarada KSaito KTaga T　The 12th Stem Cell Research Symposium　2014-05-30 Analysis of recipients transplantated with the bone marrow cells of Sox17-transduced cells-transplanted mice　Nobuhisa IOsawa MHarada KAnani MSaito KTakagi HTaga T　The 42nd Annual Meeting of The Japanese Society for Immunology　2013-12-11 Analysis of recipients transplantated with the bone marrow cells of Sox17-transduced cells-transplanted mice　Nobuhisa IOsawa MHarada KAnani MSaito KTakagi HTaga T　The 42nd Annual Meeting of The Japanese Society for Immunology　2013-12-11 Thrombopoietin contributes to formation and maintenance of hematopoietic progenitor cell-containing cell clusters in the aorta-gonad-mesonephros region　Harada, KNobuhisa IAnani MSaito KTaga T　The 36th Annual Meeting of the Molecular Biology Society of Japan　2013-12-03 Introduction of Sox17 in the aorta-gonad-mesonephros-derived hematopoietic cells leads to increased common myeloid progenitors in transplanted mice　Nobuhisa IOsawa MUemura MKishikawa YAnani MHarada KTakagi HKanai MKanai YIwama ATaga T　The 36th Annual Meeting of the Molecular Biology Society of Japan　2013-12-03 Thrombopoietin contributes to formation and maintenance of hematopoietic progenitor cell-containing cell clusters in the aorta-gonad-mesonephros region　Harada, KNobuhisa IAnani MSaito KTaga T　The 36th Annual Meeting of the Molecular Biology Society of Japan　2013-12-03 Introduction of Sox17 in the aorta-gonad-mesonephros-derived hematopoietic cells leads to increased common myeloid progenitors in transplanted mice　Nobuhisa IOsawa MUemura MKishikawa YAnani MHarada KTakagi HKanai MKanai YIwama ATaga T　The 36th Annual Meeting of the Molecular Biology Society of Japan　2013-12-03 Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by Sox17　Nobuhisa I　The 8th International Symposium of the Institute Network　2013-06-27 Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by Sox17　Nobuhisa I　The 8th International Symposium of the Institute Network　2013-06-27 Maintenance of C6 glioma side population with stemness by the cellular and synthetic niche　Tabu KBizen NKokubu YMuramatsu NNobuhisa IKagawa TTaga T　The 34th Annual Meeting of the Molecular Biology Society of Japan　2012-12-14 Maintenance of C6 glioma side population with stemness by the cellular and synthetic niche　Tabu KBizen NKokubu YMuramatsu NNobuhisa IKagawa TTaga T　The 34th Annual Meeting of the Molecular Biology Society of Japan　2012-12-14 Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by SoxF family proteins　Nobuhisa IKishikawa YAnani MTaga T　The 34th Annual Meeting of the Molecular Biology Society of Japan　2012-12-13 Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by SoxF family proteins　Nobuhisa IKishikawa YAnani MTaga T　The 34th Annual Meeting of the Molecular Biology Society of Japan　2012-12-13 Sox17 protein-mediated maintenance of cells with stem cell phenotype in the hematopoietic cell clusters in the fetal AGM region　Nobuhisa IOsawa MUemura MKishikawa YAnani MHarada KTakagi HKanai MKanai YIwama ATaga T　The 35th Annual Meeting of the Molecular Biology Society of Japan　2012-12-11 Sox17 protein-mediated maintenance of cells with stem cell phenotype in the hematopoietic cell clusters in the fetal AGM region　Nobuhisa IOsawa MUemura MKishikawa YAnani MHarada KTakagi HKanai MKanai YIwama ATaga T　The 35th Annual Meeting of the Molecular Biology Society of Japan　2012-12-11 Hematopoietic cell clusters from the aorta-gonad-mesonephros region exhibited long-term repopulating ability by overexpression of Sox17　Nobuhisa IOsawa MHarada KTakagi HIwama ATaga T　The 41st Annual Meeting of The Japanese Society for Immunology　2012-12-05 Hematopoietic cell clusters from the aorta-gonad-mesonephros region exhibited long-term repopulating ability by overexpression of Sox17　Nobuhisa IOsawa MHarada KTakagi HIwama ATaga T　The 41st Annual Meeting of The Japanese Society for Immunology　2012-12-05 Sox-F family proteins have roles in the maintenance of immature phenotype of the hemapoietic cell clusters in the aorta-gonad-mesonephros region of mouse embryos　Nobuhisa IOsawa MUemura MKishikawa YAnani MHarada KTakagi HAndo AKanai MKanai YIwama ATaga T　The 10th Annual Meeting of International Society for Stem Cell Research　2012-06-13 Cellular heterogeneity contributes to tumor stem cell maintenance in C6 glioma　Tabu KBizen NKokubu YMuramatsu NNobuhisa IKagawa TTaga T　The 10th Annual Meeting of International Society for Stem Cell Research　2012-06-13 Characterization of bone marrow derived-macrophages stimulated by C6 glioma stem cells　Muramatsu NTabu KNobuhisa IKagawa TTaga T　The 10th Annual Meeting of International Society for Stem Cell Research　2012-06-13 Sox-F family proteins have roles in the maintenance of immature phenotype of the hemapoietic cell clusters in the aorta-gonad-mesonephros region of mouse embryos　Nobuhisa IOsawa MUemura MKishikawa YAnani MHarada KTakagi HAndo AKanai MKanai YIwama ATaga T　The 10th Annual Meeting of International Society for Stem Cell Research　2012-06-13 Cellular heterogeneity contributes to tumor stem cell maintenance in C6 glioma　Tabu KBizen NKokubu YMuramatsu NNobuhisa IKagawa TTaga T　The 10th Annual Meeting of International Society for Stem Cell Research　2012-06-13 Characterization of bone marrow derived-macrophages stimulated by C6 glioma stem cells　Muramatsu NTabu KNobuhisa IKagawa TTaga T　The 10th Annual Meeting of International Society for Stem Cell Research　2012-06-13 SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region　Nobuhisa IKishikawa YAnani MTaga T　The 40th Annual Meeting of The Japanese Society for Immunology　2011-11-27 SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region　Nobuhisa IKishikawa YAnani MTaga T　The 40th Annual Meeting of The Japanese Society for Immunology　2011-11-27 Specification of Glial Cell Types in the Developing Central Nervous System　Kagawa TBizen NKashiwagi TNobuhisa IShimizu TTaga T　The 54th Annual Meeting of The Japanese Society for Neurochemistry　2011-09-28 Specification of Glial Cell Types in the Developing Central Nervous System　Kagawa TBizen NKashiwagi TNobuhisa IShimizu TTaga T　The 54th Annual Meeting of The Japanese Society for Neurochemistry　2011-09-28 Role of SoxF family proteins in the maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region　Nobuhisa IKishikawa YUemura MAnani MGomma AKanai MKanai YTaga T　The 9th Annual Meeting of International Society for Stem Cell Research　2011-05-13 Role of SoxF family proteins in the maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region　Nobuhisa IKishikawa YUemura MAnani MGomma AKanai MKanai YTaga T　The 9th Annual Meeting of International Society for Stem Cell Research　2011-05-13 Role of Sox-17 in hamatopoietic progenitors from the aorta-gonad-mesonephros region maintains immature phenotype　Nobuhisa IKishikawa YUemura MAnani MGomma AKanai MKanai YTaga T　The 32nd Annual Meeting of the Molecular Biology Society of Japan　2010-12-09 Role of Sox-17 in hamatopoietic progenitors from the aorta-gonad-mesonephros region maintains immature phenotype　Nobuhisa IKishikawa YUemura MAnani MGomma AKanai MKanai YTaga T　The 32nd Annual Meeting of the Molecular Biology Society of Japan　2010-12-09 Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system　Kagawa TNomura RShimizu TAraki KTakeda NNakagata NNobuhisa ITaga T　Neuro2010　2010-09-01 Analysis of glial cell sub-lineages in the developing central nervous system using GFAP/Cre-reporter mouse system　Kagawa TNomura RShimizu TAraki KTakeda NNakagata NNobuhisa ITaga T　Neuro2010　2010-09-01 Cells that have hematopoietic activity in the placenta of mouse embryo reside in the side population　Ramadan ANobuhisa IYamasaki STaga T　The 8th Annual Meeting of International Society for Stem Cell Research　2010-05-13 C6 glioma main population maintains side population　Tabu KKokubu YBizen NNobuhisa IKagawa TTaga T　The 8th Annual Meeting of International Society for Stem Cell Research　2010-05-13 Cells that have hematopoietic activity in the placenta of mouse embryo reside in the side population　Ramadan ANobuhisa IYamasaki STaga T　The 8th Annual Meeting of International Society for Stem Cell Research　2010-05-13 C6 glioma main population maintains side population　Tabu KKokubu YBizen NNobuhisa IKagawa TTaga T　The 8th Annual Meeting of International Society for Stem Cell Research　2010-05-13 Sox-17 maintains immature phenotype of hamatopoietic progenitors in the aorta-gonad-mesonephros region　Nobuhisa IKishikawa YYamasaki SGomma ATaga T　The 32nd Annual Meeting of the Molecular Biology Society of Japan　2009-12-09 Characterization of cells that have hematopoietic activity in the placenta of mouse embryo　Gomma ANobuhisa IYamasaki STaga T　The 39th Annual Meeting of The Japanese Society for Immunology　2009-12-02 Characterization of cells that have hematopoietic activity in the placenta of mouse embryo　Gomma ANobuhisa IYamasaki STaga T　The 7th Annual Meeting of International Society for Stem Cell Research　2009-05-15 CD45およびc-Kitの発現により分画したマウス胎仔造血組織より得た未分化細胞の解析　信久幾夫岸川陽子山崎奨太郎Gomaa Ahmed田賀哲也　The 31st Annual Meeting of the Molecular Biology Society of Japan　2008-12-09 Identification of yolk sac cells having hematopoietic activity in view of CD45/c-Kit expression　Yamasaki SNobuhisa IGomma ATaga T　The 38th Annual Meeting of The Japanese Society for Immunology　2008-12-01 マウス胎生中期の造血組織に存在する未分化血球細胞集団の同定　信久幾夫大津直樹山崎奨太郎田賀哲也　The 6th Annual Meeting of International Society for Stem Cell Research　2008-05-16 マウス胎生中期のAGMに存在する未分化血球細胞の検討　信久幾夫山崎奨太郎Gomaa Ahmed田賀哲也　第30回日本分子生物学会年会•第80回日本生化学会大会 合同大会　2007-12-11 マウス胎生中期の造血組織に存在する未分化血球細胞集団の同定　信久幾夫山崎奨太郎Gomaa Ahmed田賀哲也　The 37th Annual Meeting of The Japanese Society for Immunology　2007-11-20 Identification of a population of cells having hematopoietic activity in the aorta-gonad-mesonephros region　Nobuhisa IOhtsu NYamasaki STaga T　The 5th Annual Meeting of International Society for Stem Cell Research　2007-05-17 Identification of a population of cells having hematopoietic activity in the aorta-gonad-mesonephros region　Nobuhisa IOhtsu NYamasaki STaga T　The 5th Annual Meeting of International Society for Stem Cell Research　2007-05-17 Identification of a side population with hematopoietic stem cell property in cultured mouse aorta-gonad-mesonephros cells　Nobuhisa IOhtsu NYamasaki STaga T　The 36th Annual Meeting of The Japanese Society for Immunology　2006-12-11 マウス胎生中期のAGM分散培養より得られる造血幹細胞の解析　信久幾夫大津直樹田賀哲也　第65回日本癌学会総会　2006-09-28 Enrichment of cells with hematopoietic stem cell property from mouse aorta-gonad-mesonephros cultures　Nobuhisa IOhtsu NTaga T　20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress　2006-06-18 HIPK2 is involved in the inhibiton of mouse aorta-gonad-mesonephros (AGM) hematopoiesis　Ohtsu NNobuhisa IMochita MTaga T　20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress　2006-06-18 NMR solution structure of the tandem SH3 domain of p47phox complexed with a p22phox derived proline-rich peptide　Ogura KNobuhisa IYuzawa STakeya RTorikai SSaikawa KSumimoto HInagaki F　20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress　2006-06-18 マウス胎生中期のAGM分散培養より得られるSP細胞の解析　Nobuhisa I　The 4th Annual Meeting of International Society for Stem Cell Research　2006-05-19 マウス胎仔AGM分散培養より生じる造血前駆細胞集団の性質　信久幾夫大津直樹田賀哲也　The 35th Annual Meeting of The Japanese Society for Immunology　2005-12-13 HIPK2による胎生期造血発生抑制機構の解析　大津直樹信久幾夫餅田みゆき田賀哲也　The 35th Annual Meeting of The Japanese Society for Immunology　2005-12-13 Characterization of hematopoietic stem/progenitor property of cells in the culture of the mouse aorta-gonad-mesonephros region　Nobuhisa IOhtsu NOkada SNakagata NTaga T　47th American society of hematology annual meeting and exposition　2005-12-10 Fetal Hematopoietic Development in the Mouse Aorta-Gonad-Mesonephros Region Is Inhibited by Homeodomain-Interacting Protein Kinase 2　Ohtsu NNobuhisa IMochita MTaga T　47th American society of hematology annual meeting and exposition　2005-12-10 Enrichment of a population of cells having hematopoietic stem/progenitor cell property from the culture of the mouse aorta-gonad-mesonephros region　Nobuhisa IOhtsu NOkada SNakagata NTaga T　熊本大学ＣＯＥ国際シンポジウム　2005-11-07 マウス胎仔AGM分散培養より生じる未分化血球細胞の解析　信久幾夫大津直樹田賀哲也　第64回日本癌学会総会　2005-09-14 マウス胎生中期のAGM分散培養より生じた未分化血球細胞の解析　信久幾夫大津直樹田賀哲也　The 3rd Annual Meeting of International Society for Stem Cell Research　2005-04-21 細胞増殖を正に制御するSTAT3と負に制御するp53の相互作用の解析　餅田みゆき信久幾夫田賀哲也　The 27th Annual Meeting of the Molecular Biology Society of Japan　2004-12-08 マウス胎仔AGM分散培養により得られる血球細胞の運命付け　信久幾夫大津直樹田賀哲也　The 27th Annual Meeting of the Molecular Biology Society of Japan　2004-12-08 胎性中期マウスのAGM領域におけるHIPK2の機能解析　大津直樹信久幾夫餅田みゆき田賀哲也　The 27th Annual Meeting of the Molecular Biology Society of Japan　2004-12-08 ホスホリパーゼA2アイソザイムの島内および島間多様性の比較　千々石崇仁弟子丸正伸信久幾夫中島欽一小川智久服巻保幸服部正策小田-上田直子大野素徳　The 27th Annual Meeting of the Molecular Biology Society of Japan　2004-12-08 マウス胎仔AGM分散培養での血球輩出および分化過程の検討　信久幾夫大津直樹田賀哲也　The 34th Annual Meeting of The Japanese Society for Immunology　2004-12-01 HIPK2は胎生期マウスの血球分化を抑制する　大津直樹信久幾夫餅田みゆき田賀哲也　The 34th Annual Meeting of The Japanese Society for Immunology　2004-12-01 抑制性アダプタータンパク質Lnkの一過性阻害による造血幹細胞及び前駆細胞の骨髄再建能制御　滝澤仁信久幾夫田賀哲也高津聖志高木智　The 34th Annual Meeting of The Japanese Society for Immunology　2004-12-01 マウス胎仔AGM分散培養での血球輩出および分化過程の解析　信久幾夫大津直樹田賀哲也　第63回日本癌学会　2004-09-29 マウス胎生中期の成体型造血を負に制御する蛋白質の解析〜Ras/MAPK経路抑制因子Spred-2について〜　信久幾夫　第28回蛋白質と酵素の構造と機能に関する九州シンポジウム　2004-07-15 Ras/MAPK 経路抑制因子Spred-2のAGM造血における機能の解析　信久幾夫加藤玲子井上博文滝沢牧子沖田圭介吉村昭彦田賀哲也　The 2nd Annual Meeting of International Society for Stem Cell Research　2004-04-26 Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation　Nobuhisa IKato RInoue HTakizawa TOkita KYoshimura ATaga T　KEYSTONE SYMPOSIA “Hematopoiesis”　2004-03-12 胎生期のマウス血球分化におけるHIPK2の役割　大津直樹信久幾夫餅田みゆき田賀哲也　The 26th Annual Meeting of the Molecular Biology Society of Japan　2003-12-10 Homeobox蛋白およびhelix-loop-helix型転写因子のクロストークによる中枢神経系の細胞系譜制御メカニズムの解析　植村篤実中島欽一近藤亨信久幾夫鹿川哲史田賀哲也　The 26th Annual Meeting of the Molecular Biology Society of Japan　2003-12-10 発生初期に致死となるELYSノックアウトマウスの解析　沖田圭介清成寛信久幾夫木村直紀相沢慎一田賀哲也　The 26th Annual Meeting of the Molecular Biology Society of Japan　2003-12-10 細胞増殖を正と負に制御するシグナルのクロストーク：STAT3とp53の相互作用の探索　餅田みゆき信久幾夫田賀哲也　The 26th Annual Meeting of the Molecular Biology Society of Japan　2003-12-10 Ras/MAPK経路抑制因子Spred-2のAGM造血における機能　信久幾夫加藤玲子井上博文滝沢牧子沖田圭介吉村昭彦田賀哲也　The 26th Annual Meeting of the Molecular Biology Society of Japan　2003-12-10 Ras/MAPK経路抑制因子Spred-2のAGM造血における機能解析　信久幾夫加藤玲子井上博文滝沢牧子沖田圭介吉村昭彦田賀哲也　The 33rd Annual Meeting of The Japanese Society for Immunology　2003-12-08 抑制性アダプタータンパク質Lnkの機能阻害は造血前駆細胞の造血能を増強する　滝澤仁権相模信久幾夫田賀哲也高津聖志高木智　The 33rd Annual Meeting of The Japanese Society for Immunology　2003-12-08 Lnk adaptor protein regulates cytokine receptor-mediated actin reorganization by activating vav2/Rac/PAK pathways　権相模滝澤仁信久幾夫田賀哲也高津聖志高木智　The 33rd Annual Meeting of The Japanese Society for Immunology　2003-12-08 AGM造血を負に制御するRas/MAPK経路抑制因子Spred-2　信久幾夫吉村昭彦田賀哲也　第62回日本癌学会総会　2003-09-25 Ras/MAPK経路抑制因子Spred1及びSpred2のノックアウトマウスの解析　加藤玲子脇岡徹大石正信木村丹香子野波篤信久幾夫田賀哲也吉村昭彦　The 25th Annual Meeting of the Molecular Biology Society of Japan　2002-12-11 ELYSはRARαと結合してレチノイン酸刺激による転写活性を増強する　沖田圭介滝沢牧子井上博文木村直紀信久幾夫田賀哲也　The 25th Annual Meeting of the Molecular Biology Society of Japan　2002-12-11 Leukemia related gene FIM has a potency to negatively regulate the differentiation into haematopoietic cells during mouse development　Inoue HNobuhisa IOkita KTakizawa MTaga T　The 25th Annual Meeting of the Molecular Biology Society of Japan　2002-12-11 Ras/MAPK経路抑制因子Spredは胎生期マウスAGM造血を負に制御する　信久幾夫加藤玲子滝沢牧子高木智井上博文沖田圭介吉村昭彦田賀哲也　The 25th Annual Meeting of the Molecular Biology Society of Japan　2002-12-11 抑制性アダプタータンパクLnkの機能ドメインの同定とその作用機構　滝澤仁権相模信久幾夫田賀哲也高津聖志高木智　The 32nd Annual Meeting of The Japanese Society for Immunology　2002-12-04 細胞内アダプター蛋白質Lnkによる細胞骨格系制御とその機能部位　權相模高木智信久幾夫田賀哲也高津聖志　The 32nd Annual Meeting of The Japanese Society for Immunology　2002-12-04 AGM造血を負に制御するアダプター蛋白質Lnk　信久幾夫高木智高津聖志田賀哲也　第61回日本癌学会総会　2002-10-03 造血幹細胞の増幅制御と細胞内アダプター蛋白質Lnkおよびその作用機構　高木智權相模信久幾夫田賀哲也高津聖志　第61回日本癌学会総会　2002-10-03 アダプター蛋白質LnkはAGM造血を負に制御する　信久幾夫滝沢牧子井上博文沖田圭介高木智田賀哲也　The 31st Annual Meeting of The Japanese Society for Immunology　2001-12-11 マウスAGM造血期におけるgp130シグナルの役割　滝沢牧子信久幾夫五十嵐勝秀上野将也沖田圭介井上博文中島欽一田賀哲也　The 31st Annual Meeting of The Japanese Society for Immunology　2001-12-11 c-Ski proto-oncoproteinはAGM領域における血球分化を抑制する　井上博文信久幾夫滝沢牧子沖田圭介田賀哲也　The 31st Annual Meeting of The Japanese Society for Immunology　2001-12-11 初期造血組織に発現する新規転写因子ELYSのゲノム構造の解析　沖田圭介木村直紀滝沢牧子上野将也信久幾夫田賀哲也　The 31st Annual Meeting of The Japanese Society for Immunology　2001-12-11 造血幹細胞の起源であるマウス胎仔背側大動脈でのendomucinの発現とその機能　上野将也五十嵐勝秀木村直紀沖田圭介滝沢牧子下村泰三高倉伸幸須田年生北村俊雄信久幾夫中島欽一田賀哲也　The 31st Annual Meeting of The Japanese Society for Immunology　2001-12-11 新規転写因子ELYSのゲノム構造の解析　沖田圭介木村直紀滝沢牧子上野将也信久幾夫田賀哲也　第74回日本生化学会大会　2001-10-25 アダプター蛋白質Lnkによる成体型造血での血球分化の阻害　信久幾夫滝沢牧子沖田圭介田賀哲也　第74回日本生化学会大会　2001-10-25 表示を折りたたむ Works(作品等)   共同研究・競争的資金等の研究課題 マウス胎生中期の大動脈血液細胞塊に生じる造血幹細胞の発生・成熟・維持機構の解明　文部科学省/日本学術振興会　2018　2020 胎生中期の大動脈に接する造血幹細胞を含む血液細胞塊の形成と幹細胞維持機構の解明　文部科学省/日本学術振興会　2014　2016 マウス胎生中期の造血発生におけるＳｏｘ１７ファミリー蛋白質の役割　文部科学省/日本学術振興会　2011-04　2014-03 人工癌幹細胞ニッチの構築による癌幹細胞維持シグナルの解明と新規治療戦略の開発　文部科学省/日本学術振興会　2010-04　2015-03 マウス胎仔造血器より直接得た未分化細胞の解析と血液発生に対する役割　文部科学省/日本学術振興会　2008-04　2010-03 全て表示する（14件） マウス胎仔の造血組織より見出した長期造血再建能を持つ造血前駆細胞に関する研究　文部科学省/日本学術振興会　2006-04　2008-03 マウス胎生中期AGM領域での造血を負に制御する分子を用いた血球分化機構の解明　文部科学省/日本学術振興会　2004-04　2006-03 細胞分化の運命付けに関わる細胞外来性シグナルと細胞内在性プログラムの相互作用解明　文部科学省/日本学術振興会　2004-03　2006-03 サイトカインシグナルに基づく幹細胞の維持・分化機構の解明　文部科学省/日本学術振興会　2002-04　2005-03 器管形成における細胞系譜制御機構の解明　文部科学省/日本学術振興会　2002-04　2004-03 マウス胎生期における造血発生システムの分化制御機構の解明　文部科学省/日本学術振興会　2002-04　2004-03 信号伝達膜蛋白質ｇｐ１３０を介したサイトカインの機能と作用機序の解析　文部科学省/日本学術振興会　2000-09　2010-03 ゲノム構築に基づく共役シグナルのクロストークによる細胞機構制御の解析　2000-09　2001-03 食細胞によるスーパーオキシド生成の制御：分子スイッチとしての蛋白質ドメイン　日本学術振興会　1998-04　2000-07 表示を折りたたむ 産業財産権   社会貢献活動 2023/05/08　2023/05/30　東京医科歯科大学(TMDU) TMDU卓越大学院生選考委員会 学外委員 2022-05-06　2022-05-27　東京医科歯科大学(TMDU) TMDU卓越大学院生選考委員会 学外委員 2021-11-05　2021-11-25　東京医科歯科大学 (TMDU)　TMDU卓越大学院生選考委員会 学外委員 2019-08-21　高大連携プログラムに基づく都立戸山高等学校からの訪問高校生の受け入れ 2019-08-21　本学の高大連携プログラムに基づく都立戸山高等学校からの訪問高校生の受け入れ 全て表示する（17件） 2019-08-01　東京医科歯科大・オープンキャンパス　サイエンスカフェ・はたらく造血幹細胞 2019-07-09　2019-07-10　TMDU　Laboratory Visit of TMDU International Summer Program (ISP) 2019 2018-08-07　大阪府立茨木高等学校からの訪問高校生の受け入れ 2018-07-23　本学の高大連携プログラムに基づく筑波大学附属高等学校からの訪問高校生の受け入れ 2017-08-03　大阪府立茨木高等学校からの訪問高校生の受け入れ 2016-08-22　本学の高大連携プログラムに基づく私立本郷高等学校からの訪問高校生の受け入れ 2016-08-03　大阪府立茨木高等学校からの訪問高校生の受け入れ 2015-08-06　本学の高大連携プログラムに基づく県立水戸第一高等学校からの訪問高校生の受け入れ 2015-08-03　大阪府立茨木高等学校からの訪問高校生の受け入れ 2014-08-29　本学の高大連携プログラムに基づく県立土浦第一高等学校からの訪問高校生の受け入れ 2014-08-29　本学の高大連携プログラムに基づく県立土浦第一高等学校からの訪問高校生の受け入れ 2011-06-17　本学の高大連携プログラムに基づく県立千葉高等学校への出張授業 表示を折りたたむ メディア報道   学術貢献活動   その他(研究者活動情報)   その他教育活動 修士・博士論文指導等