ブルワーズ対カブス

× {{flash.message}} Toggle navigation Toggle navigation 日本語 | English 新規登録ログイン 細川 まゆ子 ホソカワ マユコ  (Mayuko Hosokawa) 更新日: 01/31 ホーム研究キーワード研究分野学歴論文MISC書籍等出版物講演・口頭発表等担当経験のある科目(授業)所属学協会Works(作品等)共同研究・競争的資金等の研究課題 論文 査読有り 2011年 Fluoride in drinking water exacerbates glomerulonephritis and induces liver damage in ICR-derived glomerulonephritis mice TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY Mayuko Hosokawa Hideo Asakawa Takaya Kaido Chiemi Sugaya Masashi Tsunoda Kazuyoshi Itai Yukio Kodama Ryoko Sugita-Konishi Ayako Takata Kazuhito Yokoyama Yoshiharu Aizawa … 全て表示 折りたたむ 巻 93 号 10 開始ページ 2072 終了ページ 2084 記述言語 英語 掲載種別 研究論文（学術雑誌） DOI 10.1080/02772248.2011.614725 出版者・発行元 TAYLOR & FRANCIS LTD To evaluate the effects of fluoride on the kidney and the liver of ICR-derived glomerulonephritis (ICGN) mice by using laboratory tests and pathological examinations, fluoride was administered to the ICGN mice at 0, 25, 50, 100, and 150 ppm in drinking water for 4 weeks and to the ICR mice, which have normal kidney function at 0 and 150 ppm. The BUN, creatinine, GOT, and GPT in the serum of each mouse were determined. When a mouse died, the sample from the day closest to the death was assigned for the mean. Pathological changes in the kidney were examined after PAS (periodic acid-Schiff) staining. All of the ICGN mice in the 150 ppm group and one of seven in the 100 ppm group died before the end of week 4, but no ICR mice died. For ICGN mice, the mean value of body weight in the 150 ppm group was significantly lower than those in 0 ppm group and other fluoride-administered groups. The mean values of relative liver and kidney weights in the 100 and 150 ppm groups were significantly lower than those in the control. The mean values of BUN, creatinine, and GPT in the 150 ppm group were significantly higher than those in the control. The thickness of the glomerular capillary wall and the increased mesangial matrix in the kidney were prominent in the fluoride-administered ICGN mice. These results suggested that fluoride severely exacerbated glomerulonephritis and tublar-intestitial changes in ICGN mice. リンク情報 DOIhttps://doi.org/10.1080/02772248.2011.614725Web of Sciencehttps://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000299740800020&DestApp=WOS_CPL ID情報 DOI : 10.1080/02772248.2011.614725ISSN : 0277-2248Web of Science ID : WOS:000299740800020 エクスポート BibTeX RIS 論文リストへ メニュー マイポータル 研究ブログ資料公開 共著者の一覧 まだ共著者が1人も登録されていません。 {{coauthor.Related.name_str}} {{coauthor.Related.last_modified}} 更新 limit"> もっとみる 2017 researchmap 利用規約